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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...

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Updated: Jun 25, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Tissue engineering in the rheumatic diseases.

Jochen Ringe1, Michael Sittinger

  • 1Tissue Engineering Laboratory and Berlin-Brandenburg Center for Regenerative Therapies, Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Tucholskystr 2, 10117 Berlin, Germany. jochen.ringe@charite.de

Arthritis Research & Therapy
|February 24, 2009
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells show promise for treating rheumatic diseases by developing into joint tissues and reducing inflammation. Their transplant-protecting qualities make them ideal for future tissue engineering applications in chronic joint conditions.

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Published on: May 21, 2013

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair
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Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Published on: March 22, 2024

Area of Science:

  • Regenerative Medicine
  • Immunology
  • Orthopedics

Background:

  • Degenerative and rheumatoid arthritis cause joint destruction, limiting current tissue engineering treatments.
  • Inflammatory joint conditions impair cartilage formation and degrade engineered tissues, hindering treatment for chronic diseases.

Purpose of the Study:

  • To explore the potential of mesenchymal stem cells (MSCs) for treating rheumatic diseases.
  • To evaluate MSCs' ability to form joint tissues and exert anti-inflammatory effects for tissue engineering.

Main Methods:

  • Investigated MSCs' differentiation into joint tissues.
  • Assessed MSCs' immunosuppressive and anti-inflammatory properties in vitro and in vivo.
  • Utilized 3D in vitro culture models for arthritis research.

Main Results:

  • MSCs demonstrated the capacity to develop into various joint tissues.
  • MSCs exhibited significant immunosuppressive and anti-inflammatory activities.
  • These properties suggest a protective role for transplanted cells.

Conclusions:

  • Mesenchymal stem cells are promising candidates for tissue engineering in rheumatic diseases due to their regenerative and immunomodulatory functions.
  • MSCs offer a potential strategy to overcome inflammatory barriers in chronic joint disease treatment.
  • Tissue engineering models using MSCs can advance arthritis research.