Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual Beneficial Effects of Topical l-Glutamine on Oral Mucositis in 5-Fluorouracil-Treated Mice.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·2026
Same author

L-Glutamine attenuates peritoneal fibrosis developed in 5-Fluorouracil-treated mice.

Experimental biology and medicine (Maywood, N.J.)·2026
Same author

Sodium propionate decreases implant-induced foreign body response in mice.

PloS one·2025
Same author

Gluten worsens non-alcoholic fatty liver disease by affecting lipogenesis and fatty acid oxidation in diet-induced obese apolipoprotein E-deficient mice.

Molecular and cellular biochemistry·2023
Same author

Amitriptyline efficacy in decreasing implant-induced foreign body reaction.

IUBMB life·2023
Same author

Oral formulation of Wnt inhibitor complex reduces inflammation and fibrosis in intraperitoneal implants in vivo.

Drug delivery and translational research·2023

Related Experiment Video

Updated: Jun 25, 2026

Vascular Balloon Injury and Intraluminal Administration in Rat Carotid Artery
09:41

Vascular Balloon Injury and Intraluminal Administration in Rat Carotid Artery

Published on: December 23, 2014

Cilostazol and pentoxifylline decrease angiogenesis, inflammation, and fibrosis in sponge-induced intraperitoneal

Juliana Barros Mendes1, Paula Peixoto Campos, Monaliza Angela Rocha

  • 1Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte/MG, Brazil, Av. Antônio Carlos 6627; Campus Pampulha, CEP: 31270-901; Cx Post 486, Brazil.

Life Sciences
|February 24, 2009
PubMed
Summary
This summary is machine-generated.

Phosphodiesterase (PDE) inhibitors, cilostazol and pentoxifylline, reduced peritoneal adhesion development in a murine model by inhibiting key components like angiogenesis and fibrosis. These findings suggest potential therapeutic benefits for preventing adhesions.

More Related Videos

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Related Experiment Videos

Last Updated: Jun 25, 2026

Vascular Balloon Injury and Intraluminal Administration in Rat Carotid Artery
09:41

Vascular Balloon Injury and Intraluminal Administration in Rat Carotid Artery

Published on: December 23, 2014

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Area of Science:

  • Peritoneal healing
  • Inflammation and fibrosis research
  • Vascular biology

Background:

  • Abdominal surgery can lead to abnormal peritoneal healing, forming adhesions.
  • Adhesion formation involves complex processes including angiogenesis, inflammation, and fibrosis.
  • Current therapeutic strategies for adhesion prevention are limited.

Purpose of the Study:

  • To investigate the efficacy of phosphodiesterase (PDE) inhibitors in controlling peritoneal adhesion development.
  • To assess the impact of PDE inhibitors on key adhesion components: angiogenesis, inflammation, and fibrosis.

Main Methods:

  • A murine model of sponge-induced peritoneal adhesion was utilized.
  • Two PDE inhibitors, cilostazol (PDE3) and pentoxifylline (PDE 1-5), were administered for 7 days.
  • Assays included hemoglobin content, VEGF, MPO, NAG, TNF-alpha, TGF-beta1, and collagen levels to evaluate angiogenesis, inflammation, and fibrosis.

Main Results:

  • Both cilostazol and pentoxifylline significantly reduced fibrovascular tissue, hemoglobin, and VEGF levels, indicating inhibition of angiogenesis.
  • Pentoxifylline, but not cilostazol, reduced neutrophil-associated NAG activity.
  • Both compounds decreased pro-inflammatory (TNF-alpha) and pro-fibrogenic (TGF-beta1) cytokines, and collagen synthesis.

Conclusions:

  • Cilostazol and pentoxifylline demonstrated efficacy in decreasing peritoneal adhesion development in a murine model.
  • The anti-adhesion effects are likely linked to cyclic nucleotide modulation via PDE inhibition.
  • Targeting these pathways with PDE inhibitors may offer a novel therapeutic approach for preventing peritoneal adhesions.