Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Cellular Adaptation I: Introduction and Atrophy01:23

Cellular Adaptation I: Introduction and Atrophy

Cells can adapt to environmental changes to maintain function and avoid injury, a process called cellular adaptation. Adapted cells exist in a reversible intermediate state with changes in size, number, phenotype, metabolism, or function. These responses help cells meet altered physiological or pathological demands; for example, enlargement of breast and uterine tissues during pregnancy. Early adaptations may enhance function, but persistent stress eventually causes tissue damage.Types of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peripheral Degenerative Retinoschisis: Imaging Evidence for Two Distinct Structural Configurations.

Retina (Philadelphia, Pa.)·2026
Same author

Traction-Induced Structural Failure States in Macular Hole Formation Revealed by Volume-Rendered Swept-Source OCT.

Retina (Philadelphia, Pa.)·2026
Same author

Macular Posterior Vitreous Detachment: Mechanical Insights from Volume-Rendered Swept-Source OCT.

Retina (Philadelphia, Pa.)·2026
Same author

Retinal Blood Velocity after Intravitreal Injection for Neovascular Age-Related Macular Degeneration with Optical Coherence Tomography Using Speckle Analysis.

Retina (Philadelphia, Pa.)·2026
Same author

Dry Retina Is Not Enough: Recentering Visual Acuity in Antivascular Endothelial Growth Factor Therapy for Neovascular AMD.

Retina (Philadelphia, Pa.)·2026
Same author

Synthetic Science from Large Language Models.

Retina (Philadelphia, Pa.)·2026

Related Experiment Video

Updated: Jun 25, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Age-related choroidal atrophy.

Richard F Spaide1

  • 1Vitreous-Retina-Macula Consultants of New York and the LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York 10022, USA. rickspaide@yahoo.com

American Journal of Ophthalmology
|February 24, 2009
PubMed
Summary

Age-related choroidal atrophy thins the choroid in older adults, potentially mimicking age-related macular degeneration (AMD) and increasing glaucoma risk. This condition affects the posterior pole, showing pigmentary changes and vessel rarefaction.

More Related Videos

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
10:24

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Published on: February 19, 2014

A Workflow to Quantitatively Determine Age-Related Macular Degeneration Lesion-Specific Variations in Fundus Autofluorescence
08:54

A Workflow to Quantitatively Determine Age-Related Macular Degeneration Lesion-Specific Variations in Fundus Autofluorescence

Published on: May 26, 2023

Related Experiment Videos

Last Updated: Jun 25, 2026

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
10:14

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography
10:24

Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

Published on: February 19, 2014

A Workflow to Quantitatively Determine Age-Related Macular Degeneration Lesion-Specific Variations in Fundus Autofluorescence
08:54

A Workflow to Quantitatively Determine Age-Related Macular Degeneration Lesion-Specific Variations in Fundus Autofluorescence

Published on: May 26, 2023

Area of Science:

  • Ophthalmology
  • Gerontology

Background:

  • Age-related choroidal atrophy is a newly defined entity impacting the aging eye.
  • Understanding its clinical characteristics is crucial for accurate diagnosis and management.

Observation:

  • A retrospective case series analyzed 28 eyes from 17 patients (mean age 80.6 years).
  • Choroidal thickness was measured using spectral-domain optical coherence tomography.
  • Exclusion criteria included high myopia, uveitis, trauma, and specific treatments.

Findings:

  • Mean subfoveal choroidal thickness was 69.8 microm, attenuating nasally.
  • Eyes without late age-related macular degeneration (AMD) showed tessellated fundus, macular pigmentary changes, and rarefied choroidal vessels.
  • Concurrent late AMD was observed in some eyes.
  • Glaucoma was present in 35.3% of patients, associated with peripapillary atrophy and severe choroidal thinning.

Implications:

  • Age-related choroidal atrophy presents with posterior pole abnormalities that can mimic or coexist with AMD.
  • Patients with this condition may have an elevated risk of developing glaucoma.
  • Further research is needed to elucidate the relationship between choroidal atrophy and glaucoma.