Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The keratoprosthesis: improved biocompatibility through design and surface modification.

S M Kirkham1, M E Dangel

  • 1Department of Ophthalmology, Ohio State University, Columbus.

Ophthalmic Surgery
|August 1, 1991
PubMed
Summary

Collagen-coated polymethyl methacrylate (PMMA) keratoprostheses showed improved biocompatibility compared to uncoated implants. This novel coating enhanced tissue integration and reduced adverse reactions in corneal implants.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Posterior capsule opacification in extracapsular cataract extraction and the triple procedure: a comparative study.

Ophthalmic surgery·1994
Same author

Intraocular cilia. Report of six cases of 6 weeks' to 32 years' duration.

Archives of ophthalmology (Chicago, Ill. : 1960)·1993
Same author

Postoperative Propionibacterium granulosum endophthalmitis.

Archives of ophthalmology (Chicago, Ill. : 1960)·1990
Same author

Varicella-zoster retinitis in human immunodeficiency virus infection. Case report.

Archives of ophthalmology (Chicago, Ill. : 1960)·1989
Same author

In vitro demonstration of human natural killing of keratocytes and corneal epithelium.

Annals of ophthalmology·1989
Same author

Retinal involvement in Morquio's syndrome (MPS IV).

Annals of ophthalmology·1985

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Tissue Engineering

Background:

  • Limited success of traditional keratoprostheses due to poor biocompatibility.
  • Need for improved corneal implant materials to enhance integration and reduce rejection.

Purpose of the Study:

  • To evaluate the biocompatibility and tissue integration of a novel type-I collagen-coated PMMA keratoprosthesis.
  • To compare the performance of coated versus uncoated PMMA implants in a corneal model.

Main Methods:

  • Comparison of covalently type-I collagen-coated PMMA keratoprostheses with identical uncoated implants.
  • Assessment of corneal melting, inflammatory response, and epithelial downgrowth over 15 months.
  • Electron microscopy to evaluate stromal collagen fiber attachment to implant surfaces.

Related Experiment Videos

Main Results:

  • Collagen-coated implants demonstrated reduced corneal melting, inflammation, and epithelial downgrowth compared to uncoated implants.
  • Electron microscopy confirmed attachment of stromal collagen fibers to coated implants, indicating enhanced integration.
  • Uncoated implants showed more significant adverse tissue reactions.

Conclusions:

  • Covalent type-I collagen coating significantly enhances the biocompatibility of PMMA keratoprostheses.
  • Collagen-coated implants show superior integration with corneal tissues.
  • This approach holds promise for improving outcomes in corneal reconstructive surgery.