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Updated: Jun 25, 2026
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A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
Amelanotic subungual melanoma: a case report
Carrie P Gosselink1, Joseph L Sindone, Bernard J Meadows
1Department of Orthopedics, University of Florida/Shands, Jacksonville, USA. carrie.gosselink@jax.ufl.edu
Summary
Amelanotic subungual melanoma, a rare cancer under the nail, is often misdiagnosed. Early diagnosis is crucial for better outcomes in this challenging melanoma subtype.
Area of Science:
- Dermatology
- Oncology
Background:
- Subungual melanoma constitutes 2-3% of all melanoma cases.
- This condition is often linked to a poor prognosis and high initial misdiagnosis rates (approx. 85%).
Observation:
- A case report details a 31-year-old male with a rapidly growing hallux mass.
- The mass was diagnosed as an ulcerated amelanotic subungual melanoma.
Findings:
- Amelanotic melanomas lack pigment, leading to frequent misdiagnosis.
- Delayed diagnosis significantly reduces the chances of a favorable outcome.
Implications:
- Highlights the importance of considering amelanotic subungual melanoma in differential diagnoses.
- Emphasizes the need for timely diagnosis and treatment to improve patient prognosis.
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