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Updated: Jun 25, 2026

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
Published on: March 25, 2022
[Cholangiocarcinomas developing on multiple bile duct hamartomas syndrome]
Laure Droy1, Christine Sagan, Jacques Paineau
1Service d'anatomie pathologique, de chirurgie digestive et de gastroentérologie et hépatologie, hôpital Nord-Laënnec, CHU de Nantes, boulevard Jacques-Monod, 44800 Saint-Herblain, France. lauredroy@hotmail.com
Abstract:
Two cases of cholangiocarcinoma arising in a background of multiple bile duct hamartomas are reported. In each case, the clinical and radiological investigations showed a liver tumor with no other concomitant disease. Tumors were resected, and microscopic examination revealed in one case a hilar cholangiocarcinoma, in the other case a peripheric cholangiocarcinoma, both being well-differentiated. It revealed also numerous bile duct hamartomas scattered throughout the liver. In one case, some bile duct hamartomas showed a gradual morphologic transition from benign to dysplastic and neoplastic epithelium. Patients with multiple bile duct hamartomas may have an increased risk of developing cholangiocarcinomas.
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