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Lung function in the aging Swedish cystic fibrosis population
Ulrika Dennersten1, Louise Lannefors, Peter Höglund
1Department of Respiratory Medicine and Allergology, Lund University Hospital, SE-221 85 Lund, Sweden. ulrika.dennersten@skane.se
Respiratory Medicine
|February 24, 2009
Summary
Swedish Cystic Fibrosis (CF) care, emphasizing daily exercise and mucus-clearing techniques, shows good lung function and a low decline rate. This approach supports long-term health in CF patients.
Area of Science:
- Pulmonary Medicine
- Pediatric Pulmonology
- Respiratory Therapy
Background:
- Swedish Cystic Fibrosis (CF) care generally aligns with international standards.
- A unique physiotherapy regimen, focusing on daily physical exercise and mucus evacuation techniques, has been employed since the early 1980s.
- Traditional methods like Postural Drainage with percussion and vibration are not utilized.
Purpose of the Study:
- To evaluate the effectiveness of the Swedish CF care package.
- To assess lung function trends and the rate of decline in the Swedish CF population.
- To analyze the impact of chronic Pseudomonas aeruginosa (Pa) colonization and baseline FEV1% predicted on lung function.
Main Methods:
- Lung function data (FEV1% predicted and VC% predicted) were collected from the entire Swedish CF population aged 7 years and older.
- Data were analyzed for two age groups: 7-17 years and >= 18 years.
- A linear mixed model was used to evaluate the impact of chronic Pa colonization and baseline FEV1% predicted.
Main Results:
- The study included 99% of the national CF population.
- Mean FEV1% predicted was 90+/-21 in the younger group and 73+/-26 in the adult group.
- Mean annual FEV1% predicted decline was low at 0.77% and 0.64% for the respective age groups.
- 40% of the adult group was 30 years or older, and 41% were chronically Pa colonized.
Conclusions:
- Swedish CF patients exhibit good lung function with a low annual rate of decline, even in older individuals.
- The specialized physiotherapy regimen appears effective in maintaining lung health.
- The significant proportion of adult CF patients highlights the growing need for comprehensive adult CF care.
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