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Updated: Jun 25, 2026

Assaying Protein Kinase Activity with Radiolabeled ATP
Published on: May 26, 2017
Protein kinase C intervention: the state of play
Jon Roffey1, Carine Rosse, Mark Linch
1Discovery Laboratory, Cancer Research Technology Limited, Wolfson Institute for Biomedical Research, London, UK.
Abstract:
Intervention in protein kinase C (PKC) has a chequered history, partly because of the poor selectivity of many inhibitors and partly a reflection of the sometimes antagonistic action of related PKC isoforms. Recent advances in targeting PKC isoforms have come from structural work on isolated kinase domains that have provided opportunities to drive selectivity through structure-based avenues. The promise of isoform selective inhibitors and the rationale for their development are discussed in the broader context of the PKC inhibitor arsenal.
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