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The influence of body mass index on mortality and bleeding among patients with or at high-risk of atherothrombotic
Koon-Hou Mak1, Deepak L Bhatt, Mingyuan Shao
1Gleneagles Medical Centre, 6 Napier Road No. 08-13, Singapore.
European Heart Journal
|February 24, 2009
Summary
Low body mass index (BMI) is linked to increased cardiovascular events and bleeding complications in patients at risk for atherothrombotic disease. This finding highlights a vulnerable patient group needing further research and targeted interventions.
Area of Science:
- Cardiology
- Clinical Research
- Epidemiology
Background:
- Atherothrombotic disease poses significant cardiovascular risk.
- The role of body mass index (BMI) in cardiovascular outcomes for this population is not fully understood.
Purpose of the Study:
- To investigate the association between BMI and cardiovascular events in individuals with or at risk of atherothrombotic disease.
Main Methods:
- Prospective observational study of 15,532 patients from the CHARISMA trial.
- Patients were followed for a median of 28 months for primary endpoints (cardiovascular death, myocardial infarction, stroke), all-cause mortality, and bleeding.
- Analysis included comparisons across BMI quartiles and continuous BMI using linear spline terms.
Main Results:
- The lowest BMI quartile showed a higher incidence of the primary endpoint, cardiovascular mortality, and all-cause mortality compared to the highest quartile.
- Lower continuous BMI was associated with increased risk of adverse cardiovascular outcomes.
- Low BMI correlated with a greater risk of moderate to severe bleeding complications, particularly in patients on dual-antiplatelet therapy.
Conclusions:
- Individuals with atherothrombotic disease and low BMI experience higher rates of cardiovascular events and bleeding complications.
- This subgroup warrants further investigation to optimize management and improve clinical outcomes.
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