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Nuclear Localization Signals and Import01:46

Nuclear Localization Signals and Import

Proteins targeted to the nucleus carry short stretches of amino acid sequences called the nuclear localization signal or NLS. Classical nuclear localization signals are of two types: monopartite and bipartite NLS. Monopartite classical NLS (cNLS) consists of a single cluster of 4-8 amino acids. Bipartite cNLS consists of two clusters of  2-3 amino acids and a 9-12 residue long proline-rich linker bridging the two clusters. Signal clusters are rich in positively charged amino acids such as...

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A new tool for oligonucleotide import into cells

Daniel C Leslie1, James P Landers

  • 1Departments of Chemistry, Universityof Virginia, Charlottesville, VA 22904, USA.

Clinical Chemistry
|February 24, 2009
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No abstract available in PubMed .

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