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Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified

Daniel J Klein1, Thomas E Edwards, Adrian R Ferré-D'Amaré

  • 1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109-1024, USA.

Nature Structural & Molecular Biology
|February 24, 2009
PubMed

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Transcriptional Regulation: Riboswitches

Riboswitches are RNA elements that regulate gene expression by altering their secondary structures in response to specific effector molecules. These elements, located in the leader regions of certain mRNAs, act as transcriptional regulators by toggling between alternative conformations to control downstream gene expression. Riboswitch-mediated regulation is a precise mechanism for modulating biosynthetic pathways, as exemplified by the riboflavin biosynthesis pathway in Bacillus...
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