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Related Experiment Video

Updated: Jun 25, 2026

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
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Published on: June 24, 2019

Orchestrating nuclear envelope disassembly and reassembly during mitosis.

Stephan Güttinger1, Eva Laurell, Ulrike Kutay

  • 1Institute of Biochemistry, Eidgenössische Technische Hochschule Zurich, HPM F11.1, Schafmattstrasse 18, 8093 Zurich, Switzerland.

Nature Reviews. Molecular Cell Biology
|February 24, 2009
PubMed
Summary

Higher eukaryotes use open mitosis, disassembling and reassembling the nuclear envelope (NE) during cell division. Recent studies reveal the molecular mechanisms and interplay between NE components and the cell

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Eukaryotic cell division necessitates significant nuclear envelope (NE) reorganization to ensure proper DNA segregation into daughter cells.
  • Higher eukaryotes employ 'open' mitosis, a complex process involving complete NE disassembly and subsequent reassembly.

Purpose of the Study:

  • To elucidate the mechanistic and molecular details of nuclear envelope reorganization during open mitosis.
  • To understand the interplay between nuclear envelope components and the mitotic machinery.

Main Methods:

  • Review of recent progress in the field of nuclear envelope dynamics during mitosis.
  • Analysis of molecular and mechanistic studies on NE reorganization.

Main Results:

  • Recent advancements have begun to uncover the intricate molecular players involved in NE remodeling during open mitosis.
  • A significant interplay between nuclear envelope components and the mitotic machinery has been identified.

Conclusions:

  • The process of nuclear envelope reorganization in open mitosis is a highly coordinated event.
  • Understanding this interplay is crucial for comprehending the fidelity of eukaryotic cell division.