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[Pathology of the collagen framework of the myocardium]
1Morphologiai Osztály Országos Traumatológiai Intézet, Budapest.
Insights
Cardiac collagen matrix integrity is vital for heart function. Its disintegration, even without myofiber necrosis, can lead to heart failure.
Area of Science:
- Cardiology
- Biomedical Engineering
- Pathology
Abstract:
The myocardial collagen matrix was studied in three groups of patients. The first group consisted of nine patients who had an isolated degradating damage of the collagen framework. In the second group the myocardial fibrillary matrix was examined in different cardiopathies. The author concluded that the collagen framework had degradated in the places of necroses and amyloid depositions, and it was bulky corresponding to fibrosis. Three persons who died suddenly in brain damages served as a control group. Integrity of the collagen matrix has an important role in the myocardial function, its desintegration--unrelated to myofiber necrosis--causes cardiac insufficiency.