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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Updated: Jun 25, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
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Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

Selenium, folate, and colon cancer.

Alexandra Connelly-Frost1, Charles Poole, Jessie A Satia

  • 1Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. FrostConsulting@hotmail.com

Nutrition and Cancer
|February 24, 2009
PubMed
Summary

High selenium and folate intake significantly reduces colon cancer risk. This association was observed in a large case-control study, with no significant bias found from weight loss or diagnosis timing.

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Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
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Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

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Last Updated: Jun 25, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
06:21

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

Area of Science:

  • Nutritional Epidemiology
  • Cancer Research
  • Trace Element Metabolism

Background:

  • Selenium is an essential trace element with a complex role in cancer risk.
  • Previous studies on selenium and colon cancer have yielded inconsistent results.
  • Understanding potential interactions and biases is crucial for accurate risk assessment.

Purpose of the Study:

  • To investigate the association between serum selenium levels and colon cancer risk.
  • To evaluate potential effect measure modifiers, specifically folate intake.
  • To assess biases related to postdiagnostic serum selenium measurements.

Main Methods:

  • A population-based case-control study (North Carolina Colon Cancer Study, n=1,691) was conducted.
  • Data on diet, lifestyle, and serum selenium levels were collected.
  • Statistical analyses examined the relationship between selenium, folate, and colon cancer risk, controlling for potential biases.

Main Results:

  • Individuals with high serum selenium (> 140 mcg/l) and high folate intake (> 354 mcg/day) showed a reduced relative risk of colon cancer (OR=0.5, 95% CI=0.4-0.8).
  • No significant increased risk was observed for high selenium with low folate, or low selenium with high folate.
  • No substantial bias was detected due to weight loss, stage at diagnosis, or time from diagnosis to blood draw.

Conclusions:

  • High serum selenium and folate levels, when occurring together, are associated with a significantly reduced risk of colon cancer.
  • Folate status is an important consideration when examining the selenium-colon cancer relationship.
  • The study design minimized bias from common confounding factors in observational research.