Related Experiment Video
Updated: Jun 25, 2026

Ammonia Fiber Expansion (AFEX) Pretreatment of Lignocellulosic Biomass
Published on: April 18, 2020
Amides from the stem bark of Fagara macrophylla
Jean Duplex Wansi1, Sarah Onyenibe Nwozo, Luc Meva'a Mbaze
1Department of Chemistry, University of Douala, Faculty of Science, Douala, Cameroon. jdwansi@yahoo.fr
Abstract:
Five new amide alkaloids, N-(4-hydroxyphenethyl)octacosanamide (1), N-(4-hydroxyphenethyl)hexacosanamide (2), N-(4-hydroxyphenethyl)decanamide (3), N-vanilloyltyramine (4), and N-[O-docosanoylvanilloyl]tyramine (5), were isolated from Fagara macrophylla, together with 15 known compounds. Their structures were established by using spectroscopic techniques, chemical reactions, and comparison with previously known analogues. A cytotoxicity assay was performed with the isolates, in which compounds 4, 8, and 9 were found to possess moderate to weak activity, with IC(50) values of 30.5, 11.5, and 13.5 microg/mL, respectively.
Related Concept Videos
Physical Properties of Amines
Fungal Phylum Ascomycota
Amines to Amides: Acylation of Amines
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary amide...