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Related Experiment Video

Updated: Jun 25, 2026

Murine Skin Transplantation

Murine Skin Transplantation

Published on: January 16, 2008

Skin allograft rejection.

Hugh I McFarland¹, Amy S Rosenberg¹

¹Food and Drug Administration, Bethesda, Maryland.

Current Protocols in Immunology

|February 25, 2009

Summary

This summary is machine-generated.

The tail-skin graft model effectively assesses T lymphocyte competence for anti-viral and tumor immunity. However, it is less sensitive than trunk skin for detecting minor histocompatibility differences.

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Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice

Published on: July 25, 2014

Area of Science:

Immunology
Transplantation Biology

Background:

Skin allograft rejection models T lymphocyte-mediated in vivo tissue destruction.
This process is crucial for anti-viral and tumor immunity.
Assessing T cell competence is vital for understanding immune responses.

Purpose of the Study:

To describe a tail-skin graft procedure for evaluating T lymphocyte competence.
To highlight the advantages of the tail-skin graft model.
To define the limitations of the tail-skin graft model.

Main Methods:

Utilizes a tail-skin graft procedure in mice.
Focuses on ease of graft preparation and resistance to nonspecific necrosis.
Does not require sacrifice of the donor mouse.

Main Results:

The tail-skin graft model is practical due to simple preparation and resistance to ischemic necrosis.
Donor mice are preserved, reducing experimental burden.
Tail skin exhibits lower sensitivity in detecting minor histocompatibility differences compared to trunk skin.

Conclusions:

The tail-skin graft model is a valuable tool for assessing T lymphocyte function in immunity.
It offers practical advantages for researchers.
It is not recommended for detecting minor histocompatibility antigens or testing genetic homogeneity.