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Updated: Jun 25, 2026
Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
An interference localized surface plasmon resonance biosensor based on the photonic structure of Au nanoparticles and
Ha Minh Hiep1, Hiroyuki Yoshikawa, Masato Saito
1School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1, Asahidai, Nomi, Ishikawa 923-1292, Japan.
Abstract:
This paper presents the experimental and simulation analysis of an original nanostructure design constructed with plasmonic gold nanoparticles and photonic thin-film multilayers of silicon dioxide (500 nm in thickness) and silicon on a substrate. Our nanostructure substrate showed a high sensitivity for various refractive index RI solutions and a prominent capacity for functionalizing alkanethiol molecules on the gold surface and demonstrates great potential in the development of a microfluidic-based biosensor for monitoring biotin-avidin interactions in real-time.
