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Updated: Jun 25, 2026

Novel Sequence Discovery by Subtractive Genomics
Published on: January 25, 2019
A novel method to analyze the similarity of biological sequences
Wei Huang1, Ying Guo, Jianmin Zhang
1Sichuan University, Chengdu, P. R. China.
Abstract:
In this paper, we propose a new method based on the 2-D graphical representation to analyze the similarity of biological sequences and classify the protein secondary structure sequences. Instead of computing some characteristics from the distance matrix, the average area surrounded by the curve and X axis is computed as a new invariant. The new method is tested on two sets: the coding sequences of 30 mitochondrial genes from NCBI and 12 protein secondary structure sequences. The similarity/disimilarity and phylogenetic tree (dendrogram) of these sequences verify the validity of our method.
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