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Updated: Jun 25, 2026

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

Published on: June 3, 2014

HSP 70 and atherosclerosis--protector or activator?

Agata Bielecka-Dabrowa¹, Marcin Barylski, Dimitri P Mikhailidis

¹Department of Molecular Cardionephrology and Hypertension, Medical University of Lodz, Lodz, Poland.

Expert Opinion on Therapeutic Targets

|February 25, 2009

Summary

Heat shock proteins (HSPs) have a controversial role in atherosclerosis. While heat shock protein 70 (HSP70) offers cellular protection, heat shock protein 60 (HSP60) may promote autoimmune responses contributing to this disease.

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A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

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A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Area of Science:

Cardiovascular Science
Immunology
Molecular Biology

Background:

Atherosclerosis is a leading cause of death.
Heat shock proteins (HSPs) protect cells from damage.
Bacterial HSPs may trigger autoimmune responses contributing to atherosclerosis.

Purpose of the Study:

To examine the roles of HSPs in atherosclerosis.

Main Methods:

Literature review.

Main Results:

The role of HSPs in atherosclerosis is debated.
Heat shock protein 60 (HSP60) may act as an autoantigen, initiating immune responses.
Heat shock protein 70 (HSP70) appears to be cytoprotective.

Conclusions:

An inverse relationship between HSP70 and atherosclerosis is suggested but not fully understood.
The therapeutic potential of HSPs in atherosclerosis requires further investigation.