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Therapeutic potential of IL-27 in multiple sclerosis?
Denise C Fitzgerald1, Abdolmohamad Rostami
1Thomas Jefferson University, Suite 200 Jefferson Hospital for Neuroscience, 900 Walnut Street, Philadelphia, PA 19107, USA.
Background:
Multiple sclerosis (MS) is a debilitating neurological disease, characterized by inflammatory demyelination and axonal degeneration in the CNS. Currently approved therapies are partially effective, however safer and more effective treatments are needed.
Objective/Methods:
To assess the therapeutic potential of the heterodimeric cytokine, IL-27 in MS, based on the current literature.
Results/Conclusions:
IL-27 exerts profound anti-inflammatory effects in several infectious and experimental autoimmune models. In particular, suppressive effects on helper T cells, which are implicated in the pathogenesis of MS, suggest that IL-27 may be therapeutically relevant in MS. However, while exciting discoveries have been made, further work is required particularly in human health and disease, to understand the diverse roles of IL-27 and its therapeutic potential.
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