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Neuropsychologic status at the age 4 years and atopy in a population-based birth cohort

J Julvez1, M Torrent, M Guxens

  • 1Centre for Research in Environmental Epidemiology, Barcelona, Spain.

Allergy
|February 25, 2009
PubMed

Insights

Children's early neurodevelopment may predict allergy risk. Lower cognitive and social scores in preschoolers were linked to a higher likelihood of developing atopy (allergic disease) by age six.

Area of Science:

  • Pediatric Allergy and Immunology
  • Developmental Psychology
  • Neuroscience

Background:

  • Existing research suggests a link between mental health and allergies.
  • However, limited cohort studies have explored neurodevelopment as a predictor of atopy.

Purpose of the Study:

  • To examine the association between neurobehavioral status in 4-year-old children and specific immunoglobulin E (IgE) levels.
  • To assess the relationship with skin prick test results at age six.

Main Methods:

  • A population-based birth cohort of 482 children was utilized.
  • Neurobehavioral data, specific IgE levels at age 4, and skin prick tests at age 6 were collected.
  • Atopy was defined by elevated IgE or positive skin prick tests.

Main Results:

  • Atopy prevalence was 12% at age 4 and 17% at age 6.
  • Lower neurobehavioral scores (general cognitive, verbal, executive function, social competence) were associated with increased risk of atopy at age 6.
  • Childhood allergic diseases (asthma, eczema, etc.) at age 6 correlated with earlier neurodevelopmental status.

Conclusions:

  • Preschool-age neuropsychological functioning is negatively associated with the development of atopy later in childhood.
  • Early neurodevelopmental assessments may offer insights into future allergy risk.
Abstract

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