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Updated: Jun 25, 2026

Preparation of Single-Cell Suspension of Mouse Thymic Epithelial Cells and Staining of Intracellular Molecules for Flow Cytometric Analysis
Published on: July 26, 2024
Neuropilins, semaphorins, and their role in thymocyte development
Daniella Arêas Mendes-da-Cruz1, Yves Lepelletier, Anne C Brignier
1Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. daniella@ioc.fiocruz.br
Abstract:
Some molecules described in the nervous system are also expressed in cells involved in the control of the immune response, suggesting they have a role as common mechanisms between neuroendocrine and immune systems. In this review, we focus on the expression and role of neuropilins (NPs) and their soluble ligands class 3 semaphorins in thymus physiology, particularly migration of developing thymocytes. We also discuss the concept of multivectorial thymocyte migration, including semaphorins, as a new individual cell migration vector.
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