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Decreased circulating CD34+ cells are associated with progression of diabetic nephropathy

H Makino1, S Okada, A Nagumo

  • 1Department of Atherosclerosis and Diabetes, National Cardiovascular Centre, Suita, Osaka, Japan. makinoh@hsp.ncvc.go.jp

Diabetic Medicine : a Journal of the British Diabetic Association
|February 25, 2009
PubMed

Insights

Decreased circulating CD34+ cells are linked to worsening diabetic nephropathy. Low CD34+ cell counts predict disease progression, highlighting their role in microvascular complications.

Area of Science:

  • Nephrology
  • Hematology
  • Endocrinology

Background:

  • Circulating CD34+ cells are vital for vascular health and neovascularization.
  • Reduced CD34+ cell counts are associated with cardiovascular disease.
  • The role of CD34+ cells in diabetic nephropathy remains unclear.

Purpose of the Study:

  • To investigate the association between circulating CD34+ cells and diabetic nephropathy.
  • To determine if CD34+ cell numbers predict the progression of kidney disease in diabetic patients.

Main Methods:

  • Measured circulating CD34+ cell counts in 85 Type 2 diabetic patients (aged 40-70).
  • Assessed patients with normoalbuminuria and microalbuminuria.
  • Correlated CD34+ cell numbers with urinary albumin excretion rate (UAER).

Main Results:

  • A significant inverse correlation was found between CD34+ cell numbers and log UAER (r = -0.289, P = 0.008).
  • Patients in the lowest quartile of CD34+ cells showed a significant UAER increase over 12 months.
  • Patients in the highest quartile of CD34+ cells exhibited stable UAER levels.

Conclusions:

  • Diminished circulating CD34+ cells are implicated in the progression of diabetic nephropathy.
  • CD34+ cell counts may serve as a predictive biomarker for diabetic nephropathy.
  • This finding underscores the role of progenitor cells in microvascular complications of diabetes.
Abstract

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