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Updated: Jun 25, 2026
Mouse Model of Pressure Ulcers After Spinal Cord Injury
Published on: March 9, 2019
A systematic review of therapeutic interventions for pressure ulcers after spinal cord injury
Mary Ann Regan1, Robert W Teasell, Dalton L Wolfe
1St. Joseph's Health Care-Parkwood Hospital, London, ON, Canada. maryann.regan@sjhc.london.on.ca
Objective:
To systematically review evidence on the prevention and treatment of pressure ulcers in those with a spinal cord injury (SCI).
Data Sources:
For this evidence-based review, the following data sources were used: MEDLINE/PubMed, CINAHL, EMBASE, and PsycINFO.
Study Selection:
To be selected for inclusion in the current review, there had to have been an intervention, studies had to have 3 or more subjects, and 50% or more of the participating group had to have an SCI.
Data Extraction:
Data extracted included study design, subject demographics, inclusion and exclusion criteria, study type, sample size, outcome measures used, and study results.
Data Synthesis:
Articles selected for this review were organized into 1 of 2 categories: prevention or treatment. Within each broad category, several smaller ones were created, and articles were grouped according to the prevention (direct or indirect) or treatment intervention discussed.
Conclusions:
Of the 26 articles selected for inclusion in the systematic review, 7 were randomized controlled trials (RCTs) that dealt with treatment for pressure ulcers, and there was 1 RCT on prevention. Despite the cost-effectiveness of prevention, little research exists on preventative interventions, and what does exist is mostly level 4 evidence. More research is needed for both prevention and treatment, but especially the former.
