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Pharmacokinetics of nicomorphine and its metabolites in man after epidural administration
P M Koopman-Kimenai1, T B Vree, M A Hasenbos
1Department of Clinical Pharmacy, Academic Hospital, Nijmegen Sint Radboud, The Netherlands.
Pharmaceutisch Weekblad. Scientific Edition
|June 21, 1991
Abstract:
In ten patients who received an epidural injection of 15 mg of nicomorphine, the compound was relatively slowly released from the epidural space and was found in plasma for approximately 1.5 h. Nicomorphine is relatively slowly metabolized into 6-nicotinoylmorphine and morphine. The rate of release is patient-dependent. The relative AUC values are 15.3% for nicomorphine, 23.9% for 6-nicotinoylmorphine and 60.8% for morphine. The mean clinical effect lasts for 18.2 +/- 10.1 h.