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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

HDL-associated factors provide additional prognostic information for coronary artery disease as determined by

Ryoko Mitsutake1, Shin-ichiro Miura, Bo Zhang

  • 1Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.

International Journal of Cardiology
|February 25, 2009
PubMed

Insights

Lower high-density lipoprotein cholesterol (HDL-C) levels may indicate the severity of coronary artery disease (CAD) as assessed by multi-detector row computed tomography (MDCT). This finding offers additional insight beyond other lipidemic factors.

Area of Science:

  • Cardiology
  • Radiology
  • Biochemistry

Background:

  • Atherosclerotic coronary artery disease (CAD) is linked to lipid profiles via invasive angiography.
  • The study investigates the association between non-invasive CAD assessment and lipidemic factors.

Purpose of the Study:

  • To test if CAD severity, determined by multi-detector row computed tomography (MDCT), correlates with lipidemic factors.
  • To explore the relationship between non-invasive CAD evaluation and various blood lipid markers.

Main Methods:

  • 195 patients with suspected CAD underwent MDCT coronary angiography.
  • Evaluated were the number of significantly stenosed vessels (VD) by MDCT, and levels of PAF-AH, FC, PL, RLP-C, apo-B, apo-C3, apo-E, and hs-CRP.
  • Patients were stratified into diabetes mellitus (DM) and non-DM groups.

Main Results:

  • HDL-associated PAF-AH was lower in the DM group.
  • MDCT-determined VD correlated with hypertension, ARB use, HDL-C, H-HDL, H-PL, H-FC, and RLP-C.
  • Multivariate analysis identified HDL-C as the strongest correlate of VD.

Conclusions:

  • Lower high-density lipoprotein cholesterol (HDL-C) levels may serve as an indicator of CAD severity.
  • HDL-C provides additional information on CAD severity compared to other lipidemic factors.
  • Non-invasive MDCT assessment of CAD severity is associated with specific lipid profiles.
Abstract

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