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Inhibition of HIV-1 replication by eIF3f

Susana T Valente1, Greg M Gilmartin, Christina Mott

  • 1Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, HHSC 1310c, 701 West 168th Street, New York, NY 10032, USA. sv2033@columbia.edu

Proceedings of the National Academy of Sciences of the United States of America
|February 25, 2009
PubMed
Summary

Eukaryotic initiation factor 3 subunit f (eIF3f) inhibits HIV-1 replication. Overexpression of eIF3f or its fragment N91-eIF3f restricts viral mRNA levels by interfering with HIV-1 mRNA 3' end processing.

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