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Related Experiment Video

Updated: Jun 25, 2026

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

Sudden unexpected death in lymphocytic hypophysitis.

Luis F Gonzalez-Cuyar¹, Fabio Tavora, Kyle Shaw

¹Department of Pathology, University of Maryland, Baltimore, MD 21201, USA.

The American Journal of Forensic Medicine and Pathology

|February 25, 2009

Summary

Lymphocytic hypophysitis, a rare pituitary inflammation, can affect multiple endocrine organs. This case highlights its potential role in sudden, unexplained death in young women.

Related Experiment Videos

Last Updated: Jun 25, 2026

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

Area of Science:

Endocrinology
Pathology

Background:

Lymphocytic hypophysitis is an uncommon inflammatory pituitary disorder primarily affecting women during the peripartum period.
Clinical manifestations vary based on hormonal deficiencies and target organ effects, with progression to multiple endocrinopathies being common.

Observation:

A case of a 23-year-old woman diagnosed post-mortem with lymphocytic hypophysitis.
The autopsy revealed concurrent infiltrates in the thyroid gland and adrenal medulla.
The patient experienced sudden, unexpected death without an apparent cause.

Findings:

The pathological findings included lymphocytic infiltration of the pituitary gland, thyroid, and adrenal medulla.
While the exact cause of death remains undetermined, endocrine dysfunction is a potential contributing factor.

Implications:

This case underscores the need for increased clinical awareness and prompt treatment of lymphocytic hypophysitis.
It suggests a possible link between endocrine dysfunction due to hypophysitis and sudden death in young women.
Routine pituitary gland examination in cases of sudden, unexplained death in young women is recommended.