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Human Pancreatic Islet Isolation: Part II: Purification and Culture of Human Islets
08:35

Human Pancreatic Islet Isolation: Part II: Purification and Culture of Human Islets

Published on: May 26, 2009

The protective effects of ulinastatin and adenosine triphosphate on islet function during islet isolation and after

Fu-rong Li, Li Qiu, Xue-fei Yang

    Pancreas
    |February 25, 2009
    PubMed
    Abstract

    No abstract available in PubMed .

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    The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
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