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Updated: Jun 25, 2026

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Convergence pattern studies of folate receptor.

Kalidoss Ramamoorthy1, Rama Shanker Verma

  • 1Stem cell and Molecular biology Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600 036 TN India.

Bioinformation
|February 25, 2009
PubMed
Summary

Evolutionary analysis reveals that genes for folic acid synthesis in lower eukaryotes have converged into functional domains of folate receptors in higher eukaryotes. This finding highlights conserved genetic patterns across diverse organisms.

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Area of Science:

  • Genomics
  • Evolutionary Biology
  • Molecular Biology

Background:

  • Folic acid is essential for cellular processes.
  • Understanding the evolution of metabolic pathways provides insights into organismal complexity.

Purpose of the Study:

  • To identify conserved gene patterns in folic acid synthesis during eukaryotic evolution.
  • To investigate the evolutionary relationship between lower and higher eukaryotic genes involved in folate metabolism.

Main Methods:

  • Sequence alignment of folic acid synthesizing genes.
  • Pattern analysis of gene sequences.
  • Comparative genomics.

Main Results:

  • Identified convergent gene patterns in folic acid synthesizing genes across higher eukaryotes.
  • Postulated convergence of lower eukaryotic folic acid synthesis genes into higher eukaryotic folate receptor functional domains.

Conclusions:

  • Suggests a significant evolutionary link between folate synthesis in lower eukaryotes and folate receptors in higher eukaryotes.
  • Highlights the role of gene convergence in shaping metabolic pathways and functional domains in eukaryotes.