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Related Concept Videos

Body Temperature01:25

Body Temperature

The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
Body Temperature01:07

Body Temperature

Body temperature reflects the equilibrium between heat production and heat loss within the body. Most heat is generated by metabolically active tissues, particularly the liver, heart, brain, kidneys, and endocrine organs. At rest, skeletal muscles contribute 20–30% of total heat production, but during vigorous exercise, this can increase up to 30–40 times.
The average body temperature is approximately 37°C (98.6°F) and typically ranges from 36.1–37.2°C (97–99°F), remaining relatively stable...
Assessing Body Temperature - Axilla01:14

Assessing Body Temperature - Axilla

Procedural Guide for Assessing Axillary Body Temperature using a Digital Thermometer:
Step 1: Perform hand hygiene and put on clean gloves to maintain infection control and prevent cross-contamination.
Step 2: Prepare the patient by explaining the procedure to ensure understanding and cooperation. Ensure privacy, expose the axilla, and inform the patient that minimal movement is crucial for an accurate reading.
Step 3: Adjust the patient’s clothing to expose only the axilla. It minimizes...
What is Homeostasis?01:16

What is Homeostasis?

Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F). Physiological...
Hemoglobin01:24

Hemoglobin

Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
Assessing Body Temperature - Temporal Artery01:19

Assessing Body Temperature - Temporal Artery

Here is a stepwise guide to assessing the body temperature at the temporal artery using a temporal artery thermometer
Step 1: Perform hand hygiene and don a fresh pair of gloves to prevent cross-infection and ensure patient safety.
Step 2: Explain the procedure to the patient to establish trust. Clear communication establishes trust with the patient, ensures they understand what to expect, promotes cooperation, and enhances comfort during the procedure.  
Step 3: Assess the patient's forehead...

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Related Experiment Video

Updated: Jun 25, 2026

A Rapid and Chemical-free Hemoglobin Assay with Photothermal Angular Light Scattering
05:18

A Rapid and Chemical-free Hemoglobin Assay with Photothermal Angular Light Scattering

Published on: December 7, 2016

Hemoglobin senses body temperature.

G M Artmann1, Ilya Digel, K F Zerlin

  • 1Division Juelich, Aachen University of Applied Sciences, Juelich, Germany. artmann@fh-aachen.de

European Biophysics Journal : EBJ
|February 25, 2009
PubMed
Summary

Human red blood cells exhibit a critical temperature transition near body temperature, affecting their passage through pipettes, volume, and internal properties. This suggests hemoglobin senses temperature, potentially via water molecule interactions.

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Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Related Experiment Videos

Last Updated: Jun 25, 2026

A Rapid and Chemical-free Hemoglobin Assay with Photothermal Angular Light Scattering
05:18

A Rapid and Chemical-free Hemoglobin Assay with Photothermal Angular Light Scattering

Published on: December 7, 2016

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Area of Science:

  • Biophysics
  • Cell Biology
  • Physical Chemistry

Background:

  • Red blood cells (RBCs) are crucial for oxygen transport.
  • Understanding RBC behavior at different temperatures is vital for physiological and pathological studies.
  • Previous research has not fully elucidated the thermal transitions within RBCs.

Purpose of the Study:

  • To investigate critical temperature transitions in human red blood cells.
  • To characterize changes in RBC physical properties near body temperature.
  • To explore the role of hemoglobin-water interactions in RBC thermal behavior.

Main Methods:

  • Micropipette aspiration experiments to assess RBC passage and volume.
  • Colloid osmotic pressure (COP) measurements.
  • Nuclear Magnetic Resonance (NMR) T(1)-relaxation time measurements.
  • Experiments conducted across a temperature range of 25°C to 39.5°C.

Main Results:

  • A distinct critical temperature (T(c)) around 36-37°C was identified for multiple RBC properties.
  • RBCs showed a transition from blocking to passing through pipettes at T(c).
  • Significant changes in RBC volume loss rate, COP, and NMR T(1)-relaxation occurred at T(c).
  • The T(c) shifted to higher temperatures when using a D(2)O buffer.

Conclusions:

  • A hemoglobin-water gel within RBCs undergoes a fluidization transition at T(c), similar to a glass or colloidal phase transition.
  • This transition is linked to a threshold number of stabilizing water molecules bound to hemoglobin, enabling partial unfolding.
  • Hemoglobin appears to sense body temperature, with this property likely encoded in its primary structure.