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Plasma matrix metalloproteinase levels do not predict tissue levels in abdominal aortic aneurysms suitable for

W Richard W Wilson1, Edward C Choke, Joseph Dawson

  • 1Department of Surgery, University of Leicester, Leicester, UK.

Vascular
|February 26, 2009
PubMed

Insights

Circulating matrix metalloproteinases (MMPs) do not predict abdominal aortic aneurysm (AAA) size. MMP-9 in the aneurysm wall showed a negative correlation with AAA diameter, but other MMPs and TIMPs did not correlate with AAA progression.

Area of Science:

  • Vascular Biology
  • Biochemistry

Background:

  • Matrix metalloproteinases (MMPs) are implicated in abdominal aortic aneurysm (AAA) pathogenesis.
  • A definitive role for MMPs in predicting AAA disease progression remains unclear.

Purpose of the Study:

  • To investigate the correlation between circulating MMP levels and AAA diameter.
  • To assess the relationship between MMP concentrations in the aneurysm wall and AAA diameter.
  • To compare plasma and aneurysm wall MMP concentrations.

Main Methods:

  • Collected preoperative plasma and intraoperative AAA wall biopsies from 31 patients.
  • Quantified MMP-1, MMP-2, MMP-3, MMP-9, TIMP-1, and TIMP-2 using ELISA.
  • Analyzed correlations using Spearman correlation.

Main Results:

  • No significant correlation was found between plasma and aneurysm wall concentrations for any MMP or TIMP.
  • A negative correlation was observed between aneurysm wall MMP-9 levels and AAA diameter (r = -0.42, p = 0.019).
  • Other correlations between plasma/tissue levels and AAA diameter were not significant.

Conclusions:

  • Circulating MMP levels do not reliably predict AAA diameter.
  • MMP-9 within the aneurysm wall may have a complex relationship with AAA size, warranting further investigation.

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