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Related Experiment Video

Updated: Jun 25, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

Cocaine-associated lower limb ischemia.

Chris G Collins¹, Deirdre Seoighe, Adrian Ireland

¹Department of Vascular Surgery, Beaumont Hospital, Dublin, Ireland.

|February 26, 2009

Summary

This summary is machine-generated.

Cocaine use can cause rare but severe pedal vessel thrombosis, leading to limb-threatening ischemia. Early recognition and treatment with anticoagulants and prostacyclin analogues are crucial for managing this condition.

Related Experiment Videos

Last Updated: Jun 25, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model

Published on: March 16, 2022

Area of Science:

Vascular Surgery
Toxicology
Cardiology

Background:

Cocaine-associated thrombosis is a known complication affecting various vascular beds.
However, thrombosis specifically affecting the pedal vessels is infrequently reported in medical literature.

Observation:

A 31-year-old male presented with severe lower limb ischemia two months after a cocaine binge.
No other embolic source was identified, and angiography revealed extensive occlusive disease in the tibioperoneal vessels.

Findings:

The patient's condition improved significantly with therapeutic interventions including heparin and a prostacyclin analogue.
This case highlights the potential for cocaine to induce critical ischemia in pedal arteries.

Implications:

Clinicians should consider cocaine-induced thrombosis in patients with acute lower limb arterial insufficiency of unknown origin.
Prompt diagnosis and management can prevent limb loss in cases of drug-induced vascular injury.