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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...

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Updated: Jun 25, 2026

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions
06:41

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions

Published on: March 22, 2018

Remodeling along the bone-screw interface.

Thomas Michael Präger1, Robert Mischkowski, Nico Laube

  • 1Department of Orthodontics, Dentofacial Orthopedics and Pedodontics, School of Dentistry, Charité-Universitätsmedizin Berlin, Berlin, Germany. Thomas-michael.praeger@charite.de

Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopadie : Organ/Official Journal Deutsche Gesellschaft Fur Kieferorthopadie
|February 26, 2009
PubMed
Summary
This summary is machine-generated.

Pre-drilling miniscrews did not significantly affect bone-screw contact or new bone formation rates. However, pre-drilling resulted in a significantly higher proportion of newly-formed bone, indicating potential benefits for osseointegration.

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3D Planning and Printing of Patient Specific Implants for Reconstruction of Bony Defects
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Published on: August 4, 2020

Area of Science:

  • Orthodontics
  • Biomaterials Science
  • Oral Surgery

Background:

  • Cortical miniscrew stability is crucial for orthodontic anchorage.
  • Bone-implant contact influences osseointegration and long-term stability.
  • Pre-drilling is a technique sometimes used during miniscrew insertion.

Purpose of the Study:

  • To compare bone remodeling at the bone-miniscrew interface with and without pre-drilling.
  • To evaluate the effect of pre-drilling on bone-screw contact and new bone formation.

Main Methods:

  • Twenty-four FAMI miniscrews were inserted into miniature pig mandibles, with half the sites pre-drilled.
  • Polychrome fluorescent labels were used to assess bone remodeling over 12 weeks.
  • Histomorphometric and fluorescent microscopy analyses were performed.

Main Results:

  • No significant difference in bone-screw contact (64% vs. 63%) or mineral apposition rate (1.6 vs. 1.7 µm/d) was found.
  • The pre-drilled group showed a significantly higher proportion of newly-formed bone (59% vs. 27%).
  • All screws achieved osseointegration without complications.

Conclusions:

  • Pre-drilling did not significantly alter bone-screw contact or new bone formation rates after 12 weeks.
  • Pre-drilling led to a greater volume of new bone formation, suggesting a potentially improved healing environment.
  • The study suggests pre-drilling may not be necessary for achieving adequate bone contact but could enhance bone regeneration.