Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Toxicity Testing in Animals

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

Drug Toxicity: Dose-Dependent Reactions

Drug Toxicity: Dose-Dependent Reactions

Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Target-switchable molecular imaging platform for 3D protein mapping in single cells by synchrotron radiation hard X-ray nanotomography.

Talanta·2026

Same author

Nano-Confined Radical Anion as An NIR-II Photothermal Immunogenic Amplifier for In Situ Cancer Vaccination.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Adaptive Protein Corona Nanoassemblies Couple Cytokine Signaling with Endogenous Antigen Transport for Systemic Cancer Immunity.

Journal of the American Chemical Society·2026

Same author

Navigating the transcytosis highway: engineering protein coronas for enhanced drug delivery across the blood-brain barrier.

Science bulletin·2026

Same author

Chiral nanoparticles drive enantiomer-specific osteogenic differentiation of stem cells and accelerate bone regeneration.

Science advances·2026

Same author

Restoration of endogenous electric fields with a glucose-powered symbiotic bioabsorbable bandage for diabetic wound healing.

Science advances·2026

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count

Published on: July 11, 2012

[Toxicological study of quantum dots].

Fangrui Yin¹, Yuxi Gao, Chunying Chen

¹Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. yinfr@ihep.ac.cn

Wei Sheng Yan Jiu = Journal of Hygiene Research

|February 26, 2009

Summary

This summary is machine-generated.

Quantum dots offer excellent optical properties for life sciences. This review examines their properties, characteristics, structure, and toxicity, focusing on recent cytotoxicity research and influencing factors.

More Related Videos

Compact Quantum Dots for Single-molecule Imaging

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications

Published on: February 6, 2016

Related Experiment Videos

Last Updated: Jun 25, 2026

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count

Solubilization and Bio-conjugation of Quantum Dots and Bacterial Toxicity Assays by Growth Curve and Plate Count

Published on: July 11, 2012

Compact Quantum Dots for Single-molecule Imaging

Compact Quantum Dots for Single-molecule Imaging

Published on: October 9, 2012

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications

Published on: February 6, 2016

Area of Science:

Nanotechnology
Biomedical Sciences
Materials Science

Context:

Quantum dots (QDs) are widely utilized in life sciences due to their superior optical properties.
Growing concerns regarding the potential toxicity of QDs necessitate thorough investigation.
Significant global research efforts are focused on understanding QD safety.

Purpose:

To review the fundamental properties and recent advancements in quantum dot characteristics and structure.
To consolidate current knowledge on quantum dot toxicity, with a specific emphasis on cytotoxicity.
To identify key factors influencing the cytotoxic effects of quantum dots.

Summary:

This paper provides an overview of quantum dot fundamentals, including their optical characteristics and structural attributes.
It details recent progress in understanding quantum dot properties and their applications in life sciences.
The review critically examines the cytotoxicity of quantum dots and factors that modulate their biological impact.

Impact:

Informs researchers about the dual nature of quantum dots: beneficial applications and potential risks.
Highlights critical areas for future research in developing safer quantum dot technologies.
Provides a foundation for risk assessment and the development of guidelines for quantum dot use in biological systems.