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Updated: Jun 25, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Efficient synthesis of spiro[chromeno[2,3-d]pyrimidine-5,3'-indoline]-tetraones by a one-pot and three-component
Khosrow Jadidi1, Ramin Ghahremanzadeh, Ayoob Bazgir
1Department of Chemistry, Shahid Beheshti University, Tehran, Iran.
Abstract:
An efficient one-pot synthesis of novel 8,9-dihydrospiro[chromeno[2,3-d]pyrimidine-5,3'-indoline]-2,2',4,6(1H,3H,7H)-tetraone derivatives by a three-component condensation reaction of barbituric acids, isatins and cyclohexane-1,3-diones in refluxing water in the presence of p-TSA for 10 h is reported. Two cyclohexane-1,3-diones, three barbituric acids, and eight substituted isatins were chosen for the library validation. Reaction of 5,5-dimethyl-cyclohexane-1,3-dione and acenaphthylene-1,2-dione with barbituric acids resulted in the formation of spiro[acenaphthylene-1,5'-chromeno[2,3-d]pyrimidine] derivatives.
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