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Epidermal growth factor and the nervous system.
1School of Life and Health Sciences, University of Delaware, Newark 19716.
Peptides
|May 1, 1991
Summary
Epidermal growth factor (EGF) is synthesized locally and enters the central nervous system (CNS), regulating neural functions. EGF influences CNS growth, survival, and neuroendocrine actions, potentially impacting disease states.
Area of Science:
- Neuroscience
- Cell Biology
- Molecular Biology
Background:
- Growth factors and receptors are integral to nervous system function.
- Epidermal Growth Factor (EGF) and its receptors are present in the central nervous system (CNS).
Purpose of the Study:
- To review the presence and functions of EGF and its receptors within the CNS.
- To explore the role of EGF in normal CNS physiology and in neurological disorders.
Main Methods:
- Literature review of studies investigating EGF synthesis, uptake, and function in the CNS.
- Analysis of evidence for EGF's involvement in neural regeneration, cell survival, and neuromodulation.
Main Results:
- EGF is synthesized locally in the CNS by various cells and can be taken up from peripheral blood.
- EGF regulates CNS growth, differentiation, maintenance, neural regeneration, and cell survival.
- EGF exerts neuromodulatory effects, influences the neuroendocrine system, and affects appetite and gastric secretion.
Conclusions:
- EGF plays a significant role in CNS physiology, including neuroprotection and regeneration.
- Dysregulation of EGF signaling may contribute to neurological manifestations in disease states, including malignancy and neurodegeneration.