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Related Experiment Video

Updated: Jun 25, 2026

Generation of Patient-Derived Podocytes from Skin Biopsies

Generation of Patient-Derived Podocytes from Skin Biopsies

Published on: May 26, 2023

[The endothelial podosome].

Elisabeth Génot¹

¹IECB/Inserm U889, 2, rue Robert Escarpit, 33600 Pessac, France. e.genot@iecb.u-bordeaux.fr

Medecine Sciences : M/S

|February 26, 2009

Summary

Podosomes, dynamic cell structures, are found in endothelial cells and aid in tissue invasion during vascular remodeling. This study explores their unique characteristics and potential roles.

Area of Science:

Cell Biology
Biochemistry

Context:

Podosomes are dynamic adhesion microdomains in monocyte-derived cells.
They feature a two-part architecture with an F-actin core and a protein ring.
Podosomes degrade extracellular matrix via metalloproteases.

Purpose:

To summarize recent advances in podosome research.
To discuss the characteristics of podosomes in endothelial cells.
To compare endothelial podosomes with monocytic podosomes and invadopodia.

Summary:

Podosomes, previously observed in monocytes, are now identified in endothelial cells.
Endothelial podosomes exhibit characteristics of both monocytic podosomes and invadopodia.
These structures are involved in tissue invasive activities during vascular remodeling.

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Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability

Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability

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Related Experiment Videos

Last Updated: Jun 25, 2026

Generation of Patient-Derived Podocytes from Skin Biopsies

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Published on: May 26, 2023

Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions

Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions

Published on: July 2, 2020

Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability

Endothelial Cell Transcytosis Assay as an In Vitro Model to Evaluate Inner Blood-Retinal Barrier Permeability

Published on: June 7, 2022

Impact:

Advances understanding of podosome function beyond monocytic cells.
Highlights the role of endothelial podosomes in vascular remodeling and tissue invasion.
Provides insights into cell migration and matrix degradation mechanisms.