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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Evolution and functions of long noncoding RNAs.

Chris P Ponting1, Peter L Oliver, Wolf Reik

  • 1MRC Functional Genomics Unit, University of Oxford, Department of Physiology, Anatomy and Genetics, South Parks Road, Oxford, OX1 3QX, UK. chris.ponting@dpag.ox.ac.uk

Cell
|February 26, 2009
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) are crucial regulatory molecules, not just transcriptional noise. This review explores their evolution, roles in gene regulation, and links to disease.

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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
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Area of Science:

  • Molecular Biology
  • Genetics
  • Genomics

Background:

  • RNA molecules perform diverse functions beyond protein synthesis.
  • Eukaryotic genomes produce numerous non-protein-coding RNA species.
  • Long noncoding RNAs (lncRNAs) represent a significant, yet understudied, class of transcripts.

Purpose of the Study:

  • To review the evolutionary origins of lncRNAs.
  • To elucidate the regulatory roles of lncRNAs in gene expression.
  • To examine the involvement of lncRNAs in human diseases.

Main Methods:

  • Literature review and synthesis of existing research on lncRNAs.
  • Analysis of evolutionary trajectories of lncRNA genes.
  • Integration of data on lncRNA functions in transcriptional and epigenetic regulation.

Main Results:

  • lncRNAs exhibit diverse evolutionary patterns.
  • lncRNAs are integral to complex gene regulatory networks.
  • Dysregulation of lncRNAs is implicated in various pathological conditions.

Conclusions:

  • lncRNAs are functionally significant and not merely transcriptional byproducts.
  • Understanding lncRNA evolution provides insights into their regulatory mechanisms.
  • lncRNAs represent promising targets for disease diagnosis and therapy.