Related Experiment Video
Updated: Jun 25, 2026

The Trier Social Stress Test Protocol for Inducing Psychological Stress
Published on: October 19, 2011
[The effect of various stressors on the QT-interval and the T-wave]
1Budapesti Szent Ferenc Kórház, Budapest Széher u. 73. 1021. andrassy@szentferenckorhaz.hu
Unlabelled:
Prolonged QT interval is associated with the generation of life-threatening arrhythmias and sudden death. However, neither the relation between QT duration and heart rate, nor the association between mental stress and QT time has been clarified.
Aim:
The relationship between QT duration and smoking, cardiovascular reactivity, and mental stress as well as newer methods of QT correction were studied.
Methods:
In six laboratory experiments 166 volunteers were studied. Smoking, treadmill exercise, mental arithmetic and videogame were applied as stressors. Besides fixed formulae, study and subject-specific QT correction methods were also used.
Results:
1. Bazett formula is not appropriate to compare QT durations. 2. Acute smoking has no effect on QT time. 3. QT changes are related to cardiovascular reactivity. 4. Mental stress may induce QT prolongation. 5. Bifid T waves often develop during mental and isometric stress.
Conclusions:
New methods for QT correction are more reliable than preformed formulae. QT prolongation and bifid T waves may be the links between mental stress and life threatening arrhythmias.
Related Concept Videos
Exercise Stress Test
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Electrocardiogram
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and the T...
Introduction to Stress and Lifestyle
Psychological Responses to Stress
Physiological Foundation of Stress
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Components of Stress
Interestingly, the hidden cube faces also experience these stresses, equal and opposite to those on the...
