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Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells

Monika Damek-Poprawa1, Tanja Diemer, Vanda S Lopes

  • 1Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

The Journal of Biological Chemistry
|February 26, 2009
PubMed
Summary

Melanoregulin (MREG) is essential for clearing engulfed material by lysosomes. Loss of MREG causes phagosome accumulation and impaired lysosome function, impacting intracellular trafficking.

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