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Palettes of vaccines and immunostimulatory monoclonal antibodies for combination

Ignacio Melero1, Ivan Martinez-Forero, Juan Dubrot

  • 1Gene Therapy Unit, Centro de Investigación Médica Aplicada (CIMA), Clinica Universitaria, Universidad de Navarra, Pamplona, Spain. imelero@unav.es

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|February 26, 2009
PubMed

Various monoclonal antibodies (mAb) target immune system molecules to enhance immunity by costimulating T cells (i.e., CD137, OX40, CD40, GITR) or interfering in coinhibitory signals (i.e., CTLA-4, PD-1). These powerful agents can be guided by cancer vaccines to enhance immunity against tumor but not self tissues. Clinically powerful therapeutic synergies are at hand.

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