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Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Stereotactic radiosurgery for radiation-induced meningiomas
Douglas Kondziolka1, Hideyuki Kano, Hilal Kanaan
1Department of Neurological Surgery, Center for Image-Guided Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. kondziolkads@upmc.edu
Neurosurgery
|February 26, 2009
Summary
Stereotactic radiosurgery (SRS) offers good tumor control for radiation-induced meningiomas, serving as a primary treatment or alternative to surgery, especially for patients with critical neurological conditions.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Radiation-induced meningiomas are a known complication of prior cranial radiation therapy.
- Management strategies for these tumors are evolving, with stereotactic radiosurgery (SRS) emerging as a potential therapeutic option.
Purpose of the Study:
- To evaluate the efficacy and safety of gamma knife radiosurgery (SRS) for treating radiation-induced meningiomas.
- To determine tumor control rates, overall survival, and morbidity associated with SRS in this patient population.
Main Methods:
- A retrospective analysis of 19 patients with 24 radiation-induced meningiomas treated with SRS.
- Patients underwent gamma knife radiosurgery with a median margin dose of 13 Gy.
- Tumor control and patient outcomes were assessed via serial imaging and follow-up.
Main Results:
- A 75% tumor control rate was observed after primary SRS.
- Overall survival rates were 94.1% at 3 years and 80.7% at 5 years post-SRS.
- Low morbidity was noted, with one case of optic neuropathy and one instance of asymptomatic peritumoral imaging changes.
Conclusions:
- SRS demonstrates satisfactory tumor control for radiation-induced meningiomas, both as a primary treatment and after resection.
- SRS is particularly valuable for patients with tumors in critical neurological locations or those unsuitable for surgical resection.
