Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripheral abnormalities in chronic heart failure.

S Adamopoulos1, A J Coats

  • 1Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK.

Postgraduate Medical Journal
|January 1, 1991
PubMed
Summary

Chronic heart failure (CHF) patients experience exercise intolerance due to skeletal muscle issues. Physical training improves muscle metabolism and exercise capacity by reducing acidification and phosphocreatine depletion during exertion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Importance of characteristics and modalities of physical activity and exercise in the management of cardiovascular health in individuals with cardiovascular risk factors: recommendations from the EACPR. Part II.

European journal of preventive cardiology·2012
Same author

Heart transplantation in a low-organ-donation environment: a single center experience.

Transplantation proceedings·2009
Same author

Clinical and prognostic implications of self-rating depression scales and plasma B-type natriuretic peptide in hospitalised patients with chronic heart failure.

Heart (British Cardiac Society)·2007
Same author

Effects of serial levosimendan infusions on left ventricular performance and plasma biomarkers of myocardial injury and neurohormonal and immune activation in patients with advanced heart failure.

Heart (British Cardiac Society)·2006
Same author

Increased C reactive protein and cardiac enzyme levels after coronary stent implantation. Is there protection by remote ischaemic preconditioning?

Heart (British Cardiac Society)·2006
Same author

Adaptive servo-ventilation and deadspace: effects on central sleep apnoea.

Journal of sleep research·2006

Area of Science:

  • Cardiology
  • Exercise Physiology
  • Skeletal Muscle Biochemistry

Background:

  • Exercise intolerance is a key morbidity factor in chronic heart failure (CHF).
  • Traditionally attributed to skeletal muscle hypoperfusion, intrinsic muscle abnormalities also contribute to exertional fatigue in CHF.

Purpose of the Study:

  • To investigate the role of skeletal muscle abnormalities in CHF exercise intolerance.
  • To evaluate the impact of physical training on skeletal muscle function and exercise capacity in CHF patients.

Main Methods:

  • Utilized 31P nuclear magnetic resonance (NMR) spectroscopy to assess skeletal muscle metabolism during exercise.
  • Analyzed muscle fiber type, atrophy, and oxidative enzyme capacity in CHF patients.
  • Assessed the effects of physical training programs on exercise performance and muscle metabolic markers.

Main Results:

  • 31P-NMR studies revealed early skeletal muscle metabolic changes in CHF, including excessive acidification and phosphocreatine depletion during exercise.
  • CHF patients exhibited muscle fiber atrophy, type I to II fiber transformation, and reduced oxidative enzyme capacity.
  • Physical training improved exercise performance, ventilation, and symptomatic status, with 31P-NMR showing reduced muscle acidification and phosphocreatine depletion post-training.

Conclusions:

  • Intrinsic skeletal muscle abnormalities significantly contribute to exercise intolerance in CHF.
  • Physical training is effective in improving exercise capacity and reversing detrimental skeletal muscle metabolic changes in CHF.
  • Training-induced improvements in CHF skeletal muscle function are dependent on heart failure severity and physical conditioning status.

Related Experiment Videos