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Methodologies for Studying B. subtilis Biofilms as a Model for Characterizing Small Molecule Biofilm Inhibitors
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Prolonged control of patterned biofilm formation by bio-inert surface chemistry

Shuyu Hou1, Erik A Burton, Ricky Lei Wu

  • 1Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA.

Chemical Communications (Cambridge, England)
|February 26, 2009
PubMed

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Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...