Related Experiment Video
Updated: Jun 25, 2026

Intrafemoral Injection of Human Hematopoietic Stem and Progenitor Cells into Immunocompromised Mice
Published on: December 8, 2023
Unrelated stem cell transplant for infantile idiopathic myelofibrosis
Jennifer Domm1, Cassie Calder, Becky Manes
1Pediatric Hematology/Oncology, Vanderbilt University, Nashville, Tennessee 37232-6310, USA. jennifer.domm@vanderbilt.edu
Abstract:
Idiopathic myelofibrosis (IMF) is a rare disease in children that can present during infancy and have a protracted course. The only known curative approach for this disease in adult patients is allogeneic stem cell transplant. We present two cases of IMF during infancy that did not resolve with supportive care measures. Both patients underwent unrelated stem cell transplant with complete resolution of their hematologic manifestations and resolution of the bone marrow fibrosis.
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