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Pentoxifylline response in alloxan-induced diabetic rats
Bulent Satar1, Oguzhan Yildiz, Erkan Karatas
1ORL Head & Neck Surgery, Gülhane Military Medical Faculty, Ankara, Turkey. bulentsatar@yahoo.com
Conclusion:
This study in rats shows that pentoxifylline may reverse detrimental effects of diabetes mellitus (DM) on the auditory system.
Objective:
To investigate whether delayed auditory brainstem responses (ABRs) induced by DM improve following pentoxifylline treatment in rats.
Materials And Methods:
Baseline ABRs were recorded in 25 ears of 13 normal-hearing rats. DM was induced by a single injection of alloxan (75 mg/kg of body weight) in all rats. Following a 1-month diabetic period, ABRs were recorded in six diabetic rats. Then, pentoxifylline treatment was administered for 6 weeks (20 mg/kg in drinking water), and final ABR testing was performed. Absolute latencies of waves I, III and V, and inter-peak latency differences (IPL) of I-V were measured in each stage of the experiment. These parameters were compared to each other in a pair-wise manner.
Results:
All wave latencies and IPL I-V were prolonged following induction of DM. Delay in waves III and V, and IPL I-V was significant (p<0.05). Pentoxifylline improved all of the wave latencies and IPL I-V, but significant improvement was observed in waves III and V (p<0.05). There was no significant difference between baseline measurements and measurements following pentoxifylline treatment.
