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Related Experiment Videos

Physical characterization of pharmaceutical solids.

H G Brittain1, S J Bogdanowich, D E Bugay

  • 1Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey 08903.

Pharmaceutical Research
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

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This review categorizes methods for pharmaceutical solid characterization into molecular, particulate, and bulk levels. It details techniques like spectroscopy and X-ray diffraction, illustrating their application with lactose modifications.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Analytical Chemistry

Background:

  • Physical characterization is crucial for understanding pharmaceutical solid behavior.
  • Various techniques exist, but a structured overview is beneficial for researchers.
  • Understanding solid-state properties impacts drug formulation and efficacy.

Purpose of the Study:

  • To present a comprehensive review of physical characterization methods for pharmaceutical solids.
  • To classify these methods based on the scale of analysis: molecular, particulate, and bulk.
  • To illustrate the application of these techniques using different forms of lactose.

Main Methods:

  • Classification of characterization techniques into molecular, particulate, and bulk levels.

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  • Detailed discussion of specific methods within each category, including spectroscopy, diffraction, and surface analysis.
  • Case study involving the physical characterization of three lactose modifications (hydrous, anhydrous, Fast-Flo).

    • Main Results:

    • Molecular-level methods include infrared spectroscopy and nuclear magnetic resonance spectrometry.
    • Particulate-level methods encompass particle morphology, size distribution, powder X-ray diffraction, and thermal analysis.
    • Bulk-level properties involve surface area, porosity, pore size distribution, and powder flow characteristics.

    Conclusions:

    • A multi-level approach to physical characterization provides a holistic understanding of pharmaceutical solids.
    • The chosen techniques effectively differentiate between various solid forms, as demonstrated by the lactose example.
    • Comprehensive physical characterization is essential for pharmaceutical development and quality control.