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Spectrophotometric prediction of the dissolution rate of carbamazepine tablets
P N Zannikos1, W I Li, J K Drennen
1Division of Medicinal Chemistry and Pharmaceutics, College of Pharmacy, University of Kentucky Medical Center, Lexington 40536-0082.
Pharmaceutical Research
|August 1, 1991
Abstract:
A near-infrared (IR) spectrophotometer, integrating optics, and parallel-vector supercomputer are employed to develop a mathematical model that predicts the dissolution rate of individual intact tablets from near-IR spectra (r2 = 0.985). Each tablet can be analyzed nondestructively by the spectrophotometer in less than 1 min. The model permits hundreds of near-IR wavelengths to be used in the determination of dissolution rate, leading to increased accuracy.