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Cefoperazone induced gastro-intestinal haemorrhage. A case report

I O Ozen1, S Moralioğlu, R Karabulut

  • 1Gazi University Medical Faculty, Department of Pediatric Surgery, Ankara, Turkey.

Acta Chirurgica Belgica
|February 27, 2009
PubMed

Insights

Cefoperazone, a cephalosporin antibiotic, can cause bleeding issues. A child with Meckel's diverticulum experienced severe gastrointestinal bleeding after surgery due to this medication.

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Pediatric Surgery

Background:

  • Cefoperazone is a third-generation cephalosporin antibiotic with broad-spectrum activity.
  • Cephalosporins containing a methylthiotetrazole side chain are known to cause hypoprothrombinemia and bleeding complications.

Observation:

  • A nine-year-old child underwent surgery for Meckel's diverticulum.
  • The patient received cefoperazone post-operatively.

Findings:

  • The child developed massive gastrointestinal bleeding on the fifth postoperative day.
  • This bleeding was attributed to cefoperazone-induced hypoprothrombinemia.

Implications:

  • Highlights a potential serious adverse effect of cefoperazone, particularly in surgical patients.
  • Suggests careful monitoring for bleeding complications in patients receiving cefoperazone, especially after gastrointestinal surgery.
  • Underscores the importance of considering drug-induced side effects in postoperative bleeding events.

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